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Severedysfunction in the various autophagy pathways (typi-cally caused by mutations) can correspondingly gener-ate severe progeroid pathology, affecting multiple organsystems, including muscle, the liver, the immune system,and the brain. During the previous non-cell-to-cell contact section under thesubheading Adenosine and DC there was a somewhat detailed description of the effectsinduced by cAMP activation of the PKA pathway. It is important to assess joint stability (e.g.,with a thicker polyethylene (PE) inlay or longer femoral head) as this might have changedduring synovectomy.
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